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Crossware Mail Signature is supported on Domino Server from version 8.0 and upwards running on the following operating systems:

Microsoft Windows
- Microsoft Windows 2003 Server Standard Edition 
- Microsoft Windows 2003 Server Enterprise Edition, Service Pack 2 
- Microsoft Windows 2003 Server x64 Edition 
- Microsoft Windows Server 2008 Standard Edition 
- Microsoft Windows Server 2008 Enterprise Edition 
- Microsoft Windows Server 2008 x64 Standard Edition 
- Microsoft Windows Server 2008 x64 Enterprise Edition
- Microsoft Windows Server 2012
- Microsoft Windows Server 2012 R2

Linux
- Novell SUSE Linux Enterprise Server (SLES) 10 x86 (32-bit) Not supported in Crossware Mail Signature ver 5.0.1.0
- Novell SUSE Linux Enterprise Server (SLES) 10 on System z (64-bit) 
- Red Hat Enterprise Linux (RHEL) 5.X (32-bit) -Not supported in Crossware Mail Signature ver 5.0.1.0
- Red Hat Enterprise Linux (RHEL) 5.X (64-bit)

Sun Solaris
- Sun Solaris 10 and above

IBM AIX
- IBM AIX 5.3 & above -Not supported in Crossware Mail Signature ver 5.0.1.0

IBM i
- IBM i 5.4 and above 

Crossware Mail Signature is supported on IBM Lotus Notes Client Version 8.0 and above running on the following operating systems:

Microsoft Windows (XP, Vista and 7)
Linux
Apple Mac OS X

It is also compatible with the following client devices:

IBM Domino Web Access
IBM Lotus iNotes
Apple iPhone running iNotes
Apple iPhone using Lotus Traveler
Windows Mobile / Common Time
Microsoft Outlook (via SMTP)
Microsoft Entourage (via SMTP)
Other Lotus Traveler Clients

Related Products: CMS DOM v4, CMS DOM v5